October 2024
Author: Dr Robert McDonald
A 13 year old girl presents with reduced vision and recurrent left eye pain on waking.
History of viral conjunctivitis some years ago. No other ocular history.
No Family history of ocular disease
VAR 6/9, VAL 6/15
Left eye OCT shown below.
What is the most likely diagnosis?
A - Nummular keratitis
Oops! Try again
B - Epithelial basement membrane dystrophy
Oops! Try again
C - Granular dystrophy
CORRECT!
D - Herpetic eye disease
Oops! Try again
Bilateral Granular dystrophy type 1 (with recurrent corneal epithelial erosions in the left eye)
What is the best course of action to a. reduce the pain in the left eye and b. improve the vision?
A - Deep anterior lamellar corneal transplantation
Oops! Try again
B - Penetrating keratoplasty
Oops! Try again
C - Photo therapeutic keratectomy
CORRECT!
D - Bandage contact lens
Oops! Try again
Answer C
This girl has Granular dystrophy type 1, which is an autosomal dominant condition affecting the TGFB1 gene. She had associated recurrent erosion of the corneal epithelium. Trans epithelial PTK was performed, ablating a combined 100 microns of tissue (approximately 50 microns of epithelium and 50 microns of stroma). Two months after the procedure, the left VA was 6/9 with no pain. Ablation to a depth that eliminates all of the lesions is not recommended as this removes too much tissue. Repeat ablation would be considered in the future, should the VA fall again and eventually an anterior lamellar transplant will probably be needed.
Left cornea 2 months after treatment
Use sliders to compare with pre treatment images


