Miranda

Bondi Junction

Hurstville

October 2024

A 13 year old girl presents with reduced vision and recurrent left eye pain on waking. History of viral conjunctivitis some years ago.  No other ocular history.

A 13 year old girl presents with reduced vision and recurrent left eye pain on waking.

History of viral conjunctivitis some years ago. No other ocular history.
No Family history of ocular disease
VAR 6/9, VAL 6/15

Left eye OCT shown below.

A 13 year old girl presents with reduced vision and recurrent left eye pain on waking. History of viral conjunctivitis some years ago.  No other ocular history.

What is the most likely diagnosis?

A - Nummular keratitis

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B - Epithelial basement membrane dystrophy

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C - Granular dystrophy

CORRECT!

D - Herpetic eye disease

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Bilateral Granular dystrophy type 1 (with recurrent corneal epithelial erosions in the left eye)

What is the best course of action to a. reduce the pain in the left eye and b. improve the vision?

A - Deep anterior lamellar corneal transplantation

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B - Penetrating keratoplasty

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C - Photo therapeutic keratectomy

CORRECT!

D - Bandage contact lens

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Answer C

This girl has Granular dystrophy type 1, which is an autosomal dominant condition affecting the TGFB1 gene. She had associated recurrent erosion of the corneal epithelium. Trans epithelial PTK was performed, ablating a combined 100 microns of tissue (approximately 50 microns of epithelium and 50 microns of stroma). Two months after the procedure, the left VA was 6/9 with no pain. Ablation to a depth that eliminates all of the lesions is not recommended as this removes too much tissue. Repeat ablation would be considered in the future, should the VA fall again and eventually an anterior lamellar transplant will probably be needed.

Left cornea 2 months after treatment

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MIRANDA

Level 1
629 Kingsway
Miranda NSW 2228

  02 9525 5190

Fax: 02 9525 0202

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BONDI JUNCTION

Park Place
Suite 606b, Level 6
3 Waverley Street
Bondi Junction NSW 2022

  02 9387 4427

Fax: 02 9388 0139

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HURSTVILLE

Suite 12, Level 2
33 MacMahon Street
Hurstville NSW 2220

  02 9579 4004

Fax: 02 9570 1377

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